Functional analyses of placental protein 13/galectin-13
نویسندگان
چکیده
منابع مشابه
Functional analyses of placental protein 13/galectin-13.
Placental protein 13 (PP13) was cloned from human term placenta. As sequence analyses, alignments and computational modelling showed its conserved structural and functional homology to members of the galectin family, the protein was designated galectin-13. Similar to human eosinophil Charcot-Leyden crystal protein/galectin-10 but not other galectins, its weak lysophospholipase activity was conf...
متن کاملPlacental Protein 13 (PP13) – A Placental Immunoregulatory Galectin Protecting Pregnancy
Galectins are glycan-binding proteins that regulate innate and adaptive immune responses, and some confer maternal-fetal immune tolerance in eutherian mammals. A chromosome 19 cluster of galectins has emerged in anthropoid primates, species with deep placentation and long gestation. Three of the five human cluster galectins are solely expressed in the placenta, where they may confer additional ...
متن کاملHomology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13).
The primary structure of the newly sequence analysed placental tissue protein 13 (PP13) was highly homologous to several members of the beta-galactoside-binding S-type lectin (galectin) family. By homology modelling, the three-dimensional structure of PP13 was built based on high-resolution crystal structures of homologues and also their characteristic 'jellyroll' fold was found in the case of ...
متن کاملMaternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia.
OBJECTIVE To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE). METHODS Serum PP13, PAPP-A and uterine artery pulsatility index (PI) were determined in a case-control study of 208 cases that developed PE including 48 that required delivery before 34 weeks (early-PE) and 416 unaffected control...
متن کاملLongitudinal determination of serum placental protein 13 during development of preeclampsia.
OBJECTIVE To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. METHODS A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2004
ISSN: 0014-2956
DOI: 10.1111/j.1432-1033.2004.04004.x